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To examine the experience of hand-foot syndrome (HFS) in patients undergoing an irinotecan (CPT-11)-based regimen of chemotherapy. Forty-six patients (21 males, 25 females) suffering from lung cancer (10), breast cancer (10), non-small cell lung cancer (11), and small cell lung cancer (15) were enrolled in this study. After the induction chemotherapy, they received the combination of irinotecan-based chemotherapy with CPT-11 (120 mg/m(2)) or irinotecan-based chemotherapy with docetaxel (60 mg/m(2)). HFS was observed in 34 (74%) of 46 patients. The incidence of HFS in the patients with lung cancer was 73% (7/10), breast cancer was 80% (8/10), non-small cell lung cancer was 70% (7/10) and small cell lung cancer was 100% (15/15). The incidence of HFS in patients with the relatively low serum uric acid ( or = 4.0 mg/dl). In patients with lung cancer, the incidence of HFS in patients with the favorable serum CA19-9 level ( or = 35 U/ml). In these patients, 4 (36%) of 11 patients with lung cancer, 4 (40%) of 10 patients with breast cancer, 1 (10%) of 10 patients with non-small cell lung cancer, and 6 (40%) of 15 patients with small cell lung cancer had grade 3 toxicity. HFS is a common adverse event in irinotecan-based chemotherapy. The incidence of HFS varies depending on tumor, serum uric acid, and CA19-9 level. The grade 3 toxicity
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